GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation

GMP-production of purified human B lymphocytes for the adoptive transfer in patients after allogeneic hematopoietic stem cell transplantation

Abstract Background We have recently shown that memory B cells from murine CMV immune donor animals adoptively transferred into immunodeficient mice were highly effective in protecting from a viral infection indicating a therapeutic potential of virus specific memory B cells. These preclinical data...

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Bibliographic Details
Main Authors: Hannes Tittlbach, Andrea Schneider, Julian Strobel, Robert Zimmermann, Stefanie Maas, Bernd Gebhardt, Georg Rauser, Michael Mach, Andreas Mackensen, Thomas H. Winkler, Julia Winkler
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Translational Medicine
Subjects:
Adoptive immunotherapy
B cells
GMP-compliant manufacturing
Online Access:http://link.springer.com/article/10.1186/s12967-017-1330-5

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http://link.springer.com/article/10.1186/s12967-017-1330-5

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