Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection.

Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection.

We previously showed that HIV-1 subtype C viruses elicit potent but highly type-specific neutralizing antibodies (nAb) within the first year of infection. In order to determine the specificity and evolution of these autologous nAbs, we examined neutralization escape in four individuals whose respons...

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Bibliographic Details
Main Authors: Penny L Moore, Nthabeleng Ranchobe, Bronwen E Lambson, Elin S Gray, Eleanor Cave, Melissa-Rose Abrahams, Gama Bandawe, Koleka Mlisana, Salim S Abdool Karim, Carolyn Williamson, Lynn Morris, CAPRISA 002 Study, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2742164?pdf=render

Internet

http://europepmc.org/articles/PMC2742164?pdf=render

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