Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter

Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter

JC-1, a cationic fluorescent dye when added to living cells, is known to be localized exclusively in mitochondria, particularly in good physiological conditions characterized by sufficient mitochondrial membrane potential (ΔΨ). The accumulation of JC-1 in these organelles leads to...

Full description

Bibliographic Details
Main Authors: Katarina Elefantova, Boris Lakatos, Jana Kubickova, Zdena Sulova, Albert Breier
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
multidrug resistance
P-glycoprotein
JC-1
mitochondrial membrane potential
tariquidar
Online Access:http://www.mdpi.com/1422-0067/19/7/1985

Internet

http://www.mdpi.com/1422-0067/19/7/1985

Similar Items