Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

The arachidonic acid cascade is a key player in inflammation, and numerous well-established drugs interfere with this pathway. Previous studies have suggested that simultaneous inhibition of 5-lipoxygenase (5-LO) and soluble epoxide hydrolase (sEH) results in synergistic anti-inflammatory effects. I...

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Bibliographic Details
Main Authors: Karin Meirer, Daniel Glatzel, Simon Kretschmer, Sandra K. Wittmann, Markus Hartmann, René Blöcher, Carlo Angioni, Gerd Geisslinger, Dieter Steinhilber, Bettina Hofmann, Robert Fürst, Ewgenij Proschak
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
soluble epoxide hydrolase
5-lipoxygenase
inflammation
designed multitarget ligands
leukocyte-endothelial cell interaction
Online Access:http://www.mdpi.com/1420-3049/22/1/45

Internet

http://www.mdpi.com/1420-3049/22/1/45

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