Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling

The T cell antigen receptor (TCR) is expressed on T cells, which orchestrate adaptive immune responses. It is composed of the ligand-binding clonotypic TCRαβ heterodimer and the non-covalently bound invariant signal-transducing CD3 complex. Among the CD3 subunits, the CD3ε cytoplasmic tail contains...

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Bibliographic Details
Main Authors: Frederike A. Hartl, Jatuporn Ngoenkam, Esmeralda Beck-Garcia, Liz Cerqueira, Piyamaporn Wipa, Pussadee Paensuwan, Prapat Suriyaphol, Pankaj Mishra, Burkhart Schraven, Stefan Günther, Sutatip Pongcharoen, Wolfgang W. A. Schamel, Susana Minguet
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
TCR
conformation
Lck
Nck
RK motif
Online Access:https://www.mdpi.com/2073-4409/10/4/834

Internet

https://www.mdpi.com/2073-4409/10/4/834

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