Concise total synthesis of two marine natural nucleosides: trachycladines A and B

Concise total synthesis of two marine natural nucleosides: trachycladines A and B

We report the first total synthesis of trachycladines A (10 steps, 34.2% overall yield) and B (11 steps, 35.0% overall yield) by using 5-deoxy-1,2,3-tri-O-acetyl-β-D-ribofuranose as the starting material. The critical step was the SnCl4 assisted regio- and steroselective deprotection of perbenzylate...

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Bibliographic Details
Main Authors: Haixin Ding, Wei Li, Zhizhong Ruan, Ruchun Yang, Zhijie Mao, Qiang Xiao, Jun Wu
Format: Article
Language:English
Published: Beilstein-Institut 2014-07-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
marine nucleosides
natural products
total synthesis
trachycladines A and B
Vorbrüggen glycosylation
Online Access:https://doi.org/10.3762/bjoc.10.176

Internet

https://doi.org/10.3762/bjoc.10.176

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