Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling

Human papillomaviruses (HPV) require the activation of the DNA damage response (DDR) in order to undergo a successful life cycle. This activation presents a challenge for the virus and the infected cell: how does viral and host replication proceed in the presence of a DDR that ordinarily arrests rep...

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Bibliographic Details
Main Authors: Molly L. Bristol, Dipon Das, Iain M. Morgan
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Viruses
Subjects:
HPV
human papillomavirus
replication
initiation
life cycle
DNA damage response
TopBP1
E1
E2
ATM (ataxia-telangiectasia mutated)
ATR (ataxia telangiectasia and Rad3 related)
DNA damage signaling
cervical cancer
head and neck cancer
homologous recombination
MRN (Mre11-Rad50-Nbs1)
Online Access:https://www.mdpi.com/1999-4915/9/10/268

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https://www.mdpi.com/1999-4915/9/10/268

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