Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways

Melatonin Protects MCAO-Induced Neuronal Loss via NR2A Mediated Prosurvival Pathways

Stroke is the significant cause of human mortality and sufferings depending upon race and demographic location. Melatonin is a potent antioxidant that exerts protective effects in differential experimental stroke models. Several mechanisms have been previously suggested for the neuroprotective effec...

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Bibliographic Details
Main Authors: Fawad Ali Shah, Gongping Liu, Lina T. Al Kury, Alam Zeb, Phil-Ok Koh, Muzaffar Abbas, Tao Li, Xifei Yang, Fang Liu, Yuhua Jiang, Shupeng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
melatonin
ischemic stroke
NMDA receptor
AMPA receptor
PI3K/AKT/GSK3 pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00297/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00297/full

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