Mild Inactivation of RE-1 Silencing Transcription Factor (REST) Reduces Susceptibility to Kainic Acid-Induced Seizures

Mild Inactivation of RE-1 Silencing Transcription Factor (REST) Reduces Susceptibility to Kainic Acid-Induced Seizures

RE-1 Silencing Transcription factor (REST) controls several steps in neural development by modulating the expression of a wide range of neural genes. Alterations in REST expression have been associated with the onset of epilepsy; however, whether such alterations are deleterious or represent a prote...

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Bibliographic Details
Main Authors: Emanuele Carminati, Federica Buffolo, Anna Rocchi, Caterina Michetti, Fabrizia Cesca, Fabio Benfenati
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
RE-1 silencing restriction factor (REST)
epilepsy
gene transcription
light-oxygen-voltage (LOV) domain
paired-amphipathic helix 1 (PAH1) domain
kainic acid
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00580/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00580/full

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