Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α

Mucin 1, a signal transduction membrane-bound mucin, is present in human disc tissue and is downregulated in vitro by exposure to IL-1ß or TNF-α

Abstract Background Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. Little is currently known about the presence or role of MUC1 in human di...

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Bibliographic Details
Main Authors: Helen E. Gruber, Jane A. Ingram, Gretchen L. Hoelscher, Emilio Marrero, Edward N. Hanley
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Musculoskeletal Disorders
Subjects:
Mucin 1
Intervertebral disc
Disc degeneration
Interleukin 1-ß
Tumor necrosis factor-α
Online Access:http://link.springer.com/article/10.1186/s12891-017-1541-1

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http://link.springer.com/article/10.1186/s12891-017-1541-1

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