The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

Eukaryotic cells must accurately and efficiently duplicate their genomes during each round of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and chromosome packaging are all challenges that the eukaryotic DNA replication machinery must successfully overcome. The re...

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Bibliographic Details
Main Authors: Adam R. Leman, Eishi Noguchi
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Genes
Subjects:
DNA replication
replisome
replication fork
genome stability
checkpoint
fork barriers
difficult-to-replicate sites
Online Access:http://www.mdpi.com/2073-4425/4/1/1

Internet

http://www.mdpi.com/2073-4425/4/1/1

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