Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles.

Increased long chain acyl-Coa synthetase activity and fatty acid import is linked to membrane synthesis for development of picornavirus replication organelles.

All positive strand (+RNA) viruses of eukaryotes replicate their genomes in association with membranes. The mechanisms of membrane remodeling in infected cells represent attractive targets for designing future therapeutics, but our understanding of this process is very limited. Elements of autophagy...

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Bibliographic Details
Main Authors: Jules A Nchoutmboube, Ekaterina G Viktorova, Alison J Scott, Lauren A Ford, Zhengtong Pei, Paul A Watkins, Robert K Ernst, George A Belov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3675155?pdf=render

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http://europepmc.org/articles/PMC3675155?pdf=render

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