Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor

The astacin protease Meprin β represents an emerging target for drug development due to its potential involvement in disorders such as acute and chronic kidney injury and fibrosis. Here, we elaborate on the structural basis of inhibition by a specific Meprin β inhibitor. Our analysis of the crystal...

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Bibliographic Details
Main Authors: Miriam Linnert, Claudia Fritz, Christian Jäger, Dagmar Schlenzig, Daniel Ramsbeck, Martin Kleinschmidt, Michael Wermann, Hans-Ulrich Demuth, Christoph Parthier, Stephan Schilling
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
Meprin B
Meprin beta
metalloproteinase
astacin
hydroxamate
SAR (structure activity relationship)
Online Access:https://www.mdpi.com/1422-0067/22/11/5651

Internet

https://www.mdpi.com/1422-0067/22/11/5651

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