RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment

RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment

Abstract Background Necroptosis is emerging as a new target for cancer immunotherapy as it is now recognized as a form of cell death that increases tumor immunogenicity, which would be especially helpful in treating immune-desert tumors. De novo synthesis of inflammatory proteins during necroptosis...

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Bibliographic Details
Main Authors: Han-Hee Park, Hwa-Ryeon Kim, Sang-Yeong Park, Sung-Min Hwang, Sun Mi Hong, Sangwook Park, Ho Chul Kang, Michael J. Morgan, Jong-Ho Cha, Dakeun Lee, Jae-Seok Roe, You-Sun Kim
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Molecular Cancer
Subjects:
RIPK3
TRIM28
NF-κB
Transcriptional regulator
Chromatin
Immunostimulatory cytokines
Online Access:https://doi.org/10.1186/s12943-021-01399-3

Internet

https://doi.org/10.1186/s12943-021-01399-3

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