Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

<p>Abstract</p> <p>Background</p> <p>The positive transcription elongation factor, P-TEFb, comprised of cyclin dependent kinase 9 (Cdk9) and cyclin T1, T2 or K regulates the productive elongation phase of RNA polymerase II (Pol II) dependent transcription of cellular an...

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Bibliographic Details
Main Authors: Nguyen Van Trung, Price Jason P, Byers Sarah A, Biglione Sebastian, Bensaude Olivier, Price David H, Maury Wendy
Format: Article
Language:English
Published: BMC 2007-07-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/47

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http://www.retrovirology.com/content/4/1/47

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