Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.

Sequence analysis of six blood pressure candidate regions in 4,178 individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) targeted sequencing study.

Genome-wide association studies (GWAS) identified multiple loci for blood pressure (BP) and hypertension. Six genes--ATP2B1, CACNB2, CYP17A1, JAG1, PLEKHA7, and SH2B3--were evaluated for sequence variation with large effects on systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pre...

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Bibliographic Details
Main Authors: Alanna C Morrison, Joshua C Bis, Shih-Jen Hwang, Georg B Ehret, Thomas Lumley, Kenneth Rice, Donna Muzny, Richard A Gibbs, Eric Boerwinkle, Bruce M Psaty, Aravinda Chakravarti, Daniel Levy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4183565?pdf=render

Internet

http://europepmc.org/articles/PMC4183565?pdf=render

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