suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

Polycomb repressive complex 2 (PRC2) is an epigenetic regulator of gene expression that possesses histone methyltransferase activity. PRC2 trimethylates lysine 27 of histone H3 proteins (H3K27me3) as a chromatin modification associated with repressed transcription of genes frequently involved in cel...

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Bibliographic Details
Main Authors: Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Format: Article
Language:English
Published: The Company of Biologists 2020-08-01
Series:Disease Models & Mechanisms
Subjects:
mpnst
leukemia
suz12
p53
nf1
ras signaling
Online Access:http://dmm.biologists.org/content/13/8/dmm042341

Internet

http://dmm.biologists.org/content/13/8/dmm042341

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