Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy

Cross-reactive Dengue virus-specific CD8+ T cells protect against Zika virus during pregnancy

Heterologous immunity can confer protection between related viruses. Here the authors show that prior exposure to Dengue virus can protect against subsequent infection with Zika virus in the context of pregnancy, and crucially can prevent demise of the fetus in murine models of infection.

Bibliographic Details
Main Authors: Jose Angel Regla-Nava, Annie Elong Ngono, Karla M. Viramontes, Anh-Thy Huynh, Ying-Ting Wang, Anh-Viet T. Nguyen, Rebecca Salgado, Anila Mamidi, Kenneth Kim, Michael S. Diamond, Sujan Shresta
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05458-0

Internet

https://doi.org/10.1038/s41467-018-05458-0

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