Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

We present a novel and readily accessible method facilitating cellular time-resolved imaging of transplanted pancreatic islets. Grafting of islets to the mouse ear pinna allows non-invasive, in vivo longitudinal imaging of events in the islets and enables improved acquisition of experimental data an...

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Bibliographic Details
Main Authors: Robert A. Benson, Fabien Garcon, Asha Recino, John R. Ferdinand, Menna R. Clatworthy, Herman Waldmann, James M. Brewer, Klaus Okkenhaug, Anne Cooke, Paul Garside, Maja Wållberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
type 1 diabetes
islets
multiphoton
imaging
immunotherapy
anti-CD3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01006/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01006/full

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