Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

The present study investigated possible mechanisms on the apoptosis induction of human leukemic cells by fucoidan, a sulfated polysaccharide found in marine algae. Fucoidan treatment of cells resulted in inhibition of growth and induction of apoptosis, as measured by 3-(4,5-dimetylthiazol-2-yl)-2,5-...

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Bibliographic Details
Main Authors: Yung Hyun Choi, Young Hyun Yoo, Nam Deuk Kim, Wun-Jae Kim, Gi-Young Kim, Hee-Jae Cha, Hyun Soo Park, Hye Jin Hwang
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Marine Drugs
Subjects:
fucoidan
leukemic cells
apoptosis
p38 MAPK
Bcl-2
Online Access:http://www.mdpi.com/1660-3397/11/7/2347

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http://www.mdpi.com/1660-3397/11/7/2347

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