Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection

Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection

Abstract Background The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi, strains JLP or Y. Methods The mRNA ex...

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Bibliographic Details
Main Authors: Mariana Gatto, Larissa Ragozo Cardoso Oliveira, Fernanda De Nuzzi Dias, João Pessoa Araújo Júnior, Carlos Roberto Gonçalves Lima, Eliana Peresi Lordelo, Rodrigo Mattos dos Santos, Cilmery Suemi Kurokawa
Format: Article
Language:English
Published: SciELO 2017-12-01
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
Chagas disease
Trypanosoma cruzi
Immune response
Cytokines
q-PCR
Online Access:http://link.springer.com/article/10.1186/s40409-017-0137-4

Internet

http://link.springer.com/article/10.1186/s40409-017-0137-4

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