Soluble CD40 Ligand in Sera of Subjects Exposed to Leishmania infantum Infection Reduces the Parasite Load in Macrophages.

Soluble CD40 Ligand in Sera of Subjects Exposed to Leishmania infantum Infection Reduces the Parasite Load in Macrophages.

While CD40L is typically a membrane glycoprotein expressed on activated T cells and platelets that binds and activates CD40 on the surface on antigen presenting cells, a soluble derivative (sCD40L) that appears to retain its biological activity after cleavage from cell membrane also exists. We recen...

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Bibliographic Details
Main Authors: Fabrícia Alvisi de Oliveira, Aline Silva Barreto, Lays G S Bomfim, Talita Rebeca S Leite, Priscila Lima Dos Santos, Roque Pacheco de Almeida, Ângela Maria da Silva, Malcolm S Duthie, Steven G Reed, Tatiana Rodrigues de Moura, Amélia Ribeiro de Jesus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4619201?pdf=render

Internet

http://europepmc.org/articles/PMC4619201?pdf=render

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