Early Histone Deacetylase Inhibition Mitigates Ischemia/Reperfusion Brain Injury by Reducing Microglia Activation and Modulating Their Phenotype

Early Histone Deacetylase Inhibition Mitigates Ischemia/Reperfusion Brain Injury by Reducing Microglia Activation and Modulating Their Phenotype

Histone deacetylase inhibitors (HDACi) are a promising therapeutic intervention for stroke. The involvement of the anti-inflammatory effects of HDACi in their neuroprotection has been reported, but the underlying mechanisms are still uncertain. Given the post-stroke inflammation is a time-dependent...

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Bibliographic Details
Main Authors: Shuyuan Li, Xiaoshuang Lu, Qian Shao, Zixin Chen, Qiong Huang, Zinan Jiao, Xiaodi Huang, Maosong Yue, Jingwen Peng, Xin Zhou, Dachong Chao, Heng Zhao, Juling Ji, Yuhua Ji, Qiuhong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Neurology
Subjects:
acute brain ischemia
HDACi
SAHA
inflammation
microglia/macrophages
polarization
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00893/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00893/full

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