Early Histone Deacetylase Inhibition Mitigates Ischemia/Reperfusion Brain Injury by Reducing Microglia Activation and Modulating Their Phenotype
Histone deacetylase inhibitors (HDACi) are a promising therapeutic intervention for stroke. The involvement of the anti-inflammatory effects of HDACi in their neuroprotection has been reported, but the underlying mechanisms are still uncertain. Given the post-stroke inflammation is a time-dependent...
Main Authors: | Shuyuan Li, Xiaoshuang Lu, Qian Shao, Zixin Chen, Qiong Huang, Zinan Jiao, Xiaodi Huang, Maosong Yue, Jingwen Peng, Xin Zhou, Dachong Chao, Heng Zhao, Juling Ji, Yuhua Ji, Qiuhong Ji |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-08-01
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Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2019.00893/full |
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