Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia.

Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia.

Aldose reductase (AR), an enzyme mediating the first step in the polyol pathway of glucose metabolism, is associated with complications of diabetes mellitus and increased cardiac ischemic injury. We investigated whether deleterious effects of AR are due to its actions specifically in cardiomyocytes....

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Bibliographic Details
Main Authors: Ni-Huiping Son, Radha Ananthakrishnan, Shuiqing Yu, Raffay S Khan, Hongfeng Jiang, Ruiping Ji, Hirokazu Akashi, Qing Li, Karen O'Shea, Shunichi Homma, Ira J Goldberg, Ravichandran Ramasamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3459912?pdf=render

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http://europepmc.org/articles/PMC3459912?pdf=render

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