Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction

The brain regulates fertility through gonadotropin-releasing hormone (GnRH) neurons. Estradiol induces negative feedback on pulsatile GnRH/luteinizing hormone (LH) release and positive feedback generating preovulatory GnRH/LH surges. Negative and positive feedbacks are postulated to be mediated by k...

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Bibliographic Details
Main Authors: Luhong Wang, Charlotte Vanacker, Laura L Burger, Tammy Barnes, Yatrik M Shah, Martin G Myers, Suzanne M Moenter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
kisspeptin
reproduction
GnRH
estrogen receptor alpha
neuroendocrine
CRISPR-Cas9
Online Access:https://elifesciences.org/articles/43999

Internet

https://elifesciences.org/articles/43999

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