A Model for Human Islet Transplantation to Immunodeficient Streptozotocin-Induced Diabetic Mice
Streptozotocin (STZ) is a cytotoxic glucose analogue that causes beta cell death and is widely used to induce experimental diabetes in rodents. The sensitivity of beta cells to STZ is species-specific and human beta cells are resistant to STZ. In experimental islet transplantation to rodents, STZ-di...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-11-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689718801006 |