Deletions of Chromosome 7q Affect Nuclear Organization and <i>HLXB9</i>Gene Expression in Hematological Disorders

Deletions of Chromosome 7q Affect Nuclear Organization and <i>HLXB9</i>Gene Expression in Hematological Disorders

The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as translocations or deletions, resulting in the reposit...

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Bibliographic Details
Main Authors: Concetta Federico, Temitayo Owoka, Denise Ragusa, Valentina Sturiale, Domenica Caponnetto, Claudia Giovanna Leotta, Francesca Bruno, Helen A. Foster, Silvia Rigamonti, Giovanni Giudici, Giovanni Cazzaniga, Joanna M. Bridger, Cristina Sisu, Salvatore Saccone, Sabrina Tosi
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
genome organization
radial positioning
chromosome deletion
<i>HLXB9</i> gene
<i>MNX1</i> gene
chromosome 7
leukemia
Online Access:https://www.mdpi.com/2072-6694/11/4/585

Internet

https://www.mdpi.com/2072-6694/11/4/585

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