Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization.

Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization.

The mammalian diaphanous-related formin (mDia1), a Rho-regulated cytoskeletal modulator, has been shown to promote T lymphocyte chemotaxis and interaction with antigen presenting cells, but the mechanisms underpinning mDia1 roles in these processes have not been defined. Here we show that mDia1(-/-)...

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Bibliographic Details
Main Authors: Baoxia Dong, Steven S Zhang, Wen Gao, Haichun Su, Jun Chen, Fuzi Jin, Ajay Bhargava, Xiequn Chen, Lars Jorgensen, Arthur S Alberts, Jinyi Zhang, Katherine A Siminovitch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3832380?pdf=render

Internet

http://europepmc.org/articles/PMC3832380?pdf=render

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