TCR Fingerprinting and Off-Target Peptide Identification

TCR Fingerprinting and Off-Target Peptide Identification

Adoptive T cell therapy using patient T cells redirected to recognize tumor-specific antigens by expressing genetically engineered high-affinity T-cell receptors (TCRs) has therapeutic potential for melanoma and other solid tumors. Clinical trials implementing genetically modified TCRs in melanoma p...

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Bibliographic Details
Main Authors: Armen R. Karapetyan, Chawaree Chaipan, Katharina Winkelbach, Sandra Wimberger, Jun Seop Jeong, Bishnu Joshi, Robert B. Stein, Dennis Underwood, John C. Castle, Marc van Dijk, Volker Seibert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
off-target prediction
cross-reactive peptides
MHC class I
NY-ESOc259
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02501/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02501/full

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