A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis

A Combined Transcriptomic and Genomic Analysis Identifies a Gene Signature Associated With the Response to Anti-TNF Therapy in Rheumatoid Arthritis

Background: Rheumatoid arthritis (RA) is the most frequent autoimmune disease involving the joints. Although anti-TNF therapies have proven effective in the management of RA, approximately one third of patients do not show a significant clinical response. The objective of this study was to identify...

Full description

Bibliographic Details
Main Authors: Adrià Aterido, Juan D. Cañete, Jesús Tornero, Francisco Blanco, Benjamín Fernández-Gutierrez, Carolina Pérez, Mercedes Alperi-López, Alex Olivè, Héctor Corominas, Víctor Martínez-Taboada, Isidoro González, Antonio Fernández-Nebro, Alba Erra, María López-Lasanta, Mireia López Corbeto, Núria Palau, Sara Marsal, Antonio Julià
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
genomics
transcriptomics
multi-omics association analysis
anti-TNF therapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01459/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01459/full

Similar Items