NF-κB p65-dependent transcriptional regulation of histone deacetylase 2 contributes to the chronic constriction injury-induced neuropathic pain via the microRNA-183/TXNIP/NLRP3 axis

NF-κB p65-dependent transcriptional regulation of histone deacetylase 2 contributes to the chronic constriction injury-induced neuropathic pain via the microRNA-183/TXNIP/NLRP3 axis

Abstract Background Neuropathic pain is related to the sustained activation of neuroglial cells and the production of proinflammatory cytokines in the spinal dorsal horn. However, the clinical efficacy of currently available treatments is very limited. The transcription factor nuclear factor κB (NF-...

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Bibliographic Details
Main Authors: Jiamin Miao, Xuelong Zhou, Tianjiao Ji, Gang Chen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Neuroinflammation
Subjects:
Neuropathic pain
Chronic constriction injury
NF-κB p65
Histone deacetylase 2
microRNA-183
TXNIP
Online Access:http://link.springer.com/article/10.1186/s12974-020-01901-6

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http://link.springer.com/article/10.1186/s12974-020-01901-6

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