RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

Chronic activation of the NF-κB pathway is associated with progressive neurodegeneration in Parkinson's disease (PD). Given the role of neuronal RING finger protein 11 (RNF11) as a negative regulator of the NF-κB pathway, in this report we investigated the function of RNF11 in dopaminergic cell...

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Bibliographic Details
Main Authors: Elaine L. Pranski, Nirjari V. Dalal, Carson Van Sanford, Jeremy H. Herskowitz, Marla Gearing, Carlos Lazo, Gary W. Miller, James J. Lah, Allan I. Levey, Ranjita S. Betarbet
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
NF-κB
E3 ligase
6-Hydroxydopamine
6-OHDA
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113000090

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http://www.sciencedirect.com/science/article/pii/S0969996113000090

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