The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

Neuroblastoma is a highly metastatic tumor that emerges from neural crest cell progenitors. Focal Adhesion Kinase (FAK) is a regulator of cell migration that binds to the receptor Neogenin-1 and is upregulated in neuroblastoma. Here, we show that Netrin-1 ligand binding to Neogenin-1 leads to FAK au...

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Bibliographic Details
Main Authors: Andrea A. Villanueva, Pilar Sanchez-Gomez, Ernesto Muñoz-Palma, Sofía Puvogel, Bárbara S. Casas, Cecilia Arriagada, Isaac Peña-Villalobos, Pablo Lois, Manuel Ramírez Orellana, Fabiana Lubieniecki, Fernando Casco Claro, Iván Gallegos, Javier García-Castro, Vicente A. Torres, Verónica Palma
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Cell Adhesion & Migration
Subjects:
netrin-1
neogenin-1
integrin-β1 activation
fak; cell migration
metastasis
neuroblastoma
Online Access:http://dx.doi.org/10.1080/19336918.2021.1892397

Internet

http://dx.doi.org/10.1080/19336918.2021.1892397

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