Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypothalamic POMC (proopiomelanocortin) neurons and their...

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Bibliographic Details
Main Authors: Paula P. Perissinotti, Elizabeth Martínez-Hernández, Yungui He, Michael D. Koob, Erika S. Piedras-Rentería
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Neuroscience
Subjects:
leptin
Kelch-like 1
CaV3.1
T-type calcium channels
POMC
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.718464/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.718464/full

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