Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer

Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.

Bibliographic Details
Main Authors: Manav Korpal, Xiaoling Puyang, Zhenhua Jeremy Wu, Roland Seiler, Craig Furman, Htoo Zarni Oo, Michael Seiler, Sean Irwin, Vanitha Subramanian, Jaya Julie Joshi, Chris K. Wang, Victoria Rimkunas, Davide Tortora, Hua Yang, Namita Kumar, Galina Kuznetsov, Mark Matijevic, Jesse Chow, Pavan Kumar, Jian Zou, Jacob Feala, Laura Corson, Ryan Henry, Anand Selvaraj, Allison Davis, Kristjan Bloudoff, James Douglas, Bernhard Kiss, Morgan Roberts, Ladan Fazli, Peter C. Black, Peter Fekkes, Peter G. Smith, Markus Warmuth, Lihua Yu, Ming-Hong Hao, Nicholas Larsen, Mads Daugaard, Ping Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00147-w

Internet

https://doi.org/10.1038/s41467-017-00147-w

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