Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs. Here we show that the nuclear m6A reader YTHDC1 is essential for embryo viability and germline development in mouse. Specifi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-05-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC5991768?pdf=render |