Differences in type I interferon signaling antagonism by dengue viruses in human and non-human primate cell lines.

Differences in type I interferon signaling antagonism by dengue viruses in human and non-human primate cell lines.

BACKGROUND/OBJECTIVES:In vitro studies have shown that dengue virus (DENV) can thwart the actions of interferon (IFN)-α/β and prevent the development of an antiviral state in infected cells. Clinical studies looking at gene expression in patients with severe dengue show a reduced expression of inter...

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Bibliographic Details
Main Authors: Freddy A Medina, Giselle Torres-Malavé, Amanda J Chase, Gilberto A Santiago, Juan F Medina, Luis M Santiago, Jorge L Muñoz-Jordán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC4359095?pdf=render

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http://europepmc.org/articles/PMC4359095?pdf=render

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