Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]

Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth[S]

Ergosterol biosynthesis and homeostasis in the parasitic protozoan Trypanosoma brucei was analyzed by RNAi silencing and inhibition of sterol C24β-methyltransferase (TbSMT) and sterol 14α-demethylase [TbSDM (TbCYP51)] to explore the functions of sterols in T. brucei growth. Inhibition of the amount...

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Bibliographic Details
Main Authors: Brad A. Haubrich, Ujjal K. Singha, Matthew B. Miller, Craigen R. Nes, Hosanna Anyatonwu, Laurence Lecordier, Presheet Patkar, David J. Leaver, Fernando Villalta, Benoit Vanhollebeke, Minu Chaudhuri, W. David Nes
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Journal of Lipid Research
Subjects:
ergosterol biosynthesis
cholesterol
sparking function
inhibitor
ribonucleic acid interference
knockdown
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356182

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http://www.sciencedirect.com/science/article/pii/S0022227520356182

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