KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix

KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix

Somatic mutations in the KRAS oncogene are associated with poor outcomes in locally advanced rectal cancer but the underlying biologic mechanisms are not fully understood. We profiled mRNA in 76 locally advanced rectal adenocarcinomas from patients that were enrolled in a prospective clinical trial...

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Bibliographic Details
Main Authors: Jin K. Kim, Michael R. Marco, Seo‐Hyun Choi, Xuan Qu, Chin‐Tung Chen, Moshe Elkabets, Lauren Fairchild, Oliver Chow, Francisco M. Barriga, Lukas E. Dow, Kevin O’Rourke, Bryan Szeglin, Dmitry Yarilin, Sho Fujisawa, Katia Manova‐Todorova, Philip B. Paty, Jinru Shia, Christina Leslie, J. Joshua Smith, Scott Lowe, Raphael Pelossof, Francisco Sanchez‐Vega, Julio Garcia‐Aguilar
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:Molecular Oncology
Subjects:
cancer‐associated fibroblast
extracellular matrix
KRAS
rectal cancer
tumor response
tumor stroma
Online Access:https://doi.org/10.1002/1878-0261.12960

Internet

https://doi.org/10.1002/1878-0261.12960

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