Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice

Gut microbiota accelerates cisplatin-induced acute liver injury associated with robust inflammation and oxidative stress in mice

Abstract Background Gut microbiota has been reported to be disrupted by cisplatin, as well as to modulate chemotherapy toxicity. However, the precise role of intestinal microbiota in the pathogenesis of cisplatin hepatotoxicity remains unknown. Methods We compared the composition and function of gut...

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Bibliographic Details
Main Authors: Shenhai Gong, Yinglin Feng, Yunong Zeng, Huanrui Zhang, Meiping Pan, Fangjie He, Rong Wu, Jingrui Chen, Jiuling Lu, Siyou Zhang, Songhua Yuan, Xia Chen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Translational Medicine
Subjects:
Gut microbiota
Cisplatin
Hepatotoxicity
Inflammation
Oxidative stress
Online Access:https://doi.org/10.1186/s12967-021-02814-5

Internet

https://doi.org/10.1186/s12967-021-02814-5

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