Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice

Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice

Toll-like receptor 4 (TLR4) plays key roles in innate immune responses and inflammatory reactions. TAK-242 (resatorvid) is a small-molecule cyclohexene derivative that selectively inhibits TLR4 signaling pathways and suppresses inflammatory reactions. Here we investigated the protective effects of T...

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Bibliographic Details
Main Authors: Yukimichi Nakano, Masamitsu Shimazawa, Kazuki Ojino, Hiroshi Izawa, Hiroto Takeuchi, Yuki Inoue, Kazuhiro Tsuruma, Hideaki Hara
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Journal of Pharmacological Sciences
Subjects:
Glaucoma
Toll-like receptor 4
TAK-242
Optic nerve crush
Retinal ganglion cell
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300361

Internet

http://www.sciencedirect.com/science/article/pii/S1347861317300361

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