BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells

BW18, a C-21 steroidal glycoside, exerts an excellent anti-leukemia activity through inducing S phase cell cycle arrest and apoptosis via MAPK pathway in K562 cells

C-21 steroids displayed the activities of immunosuppressive, anti-inflammatory and anti-virus effects by the reports. However, its antitumor effects and molecular mechanism remain unclear. We previously isolated and identified a C-21 steroidal glycoside (BW18) from the root of Cynanchum atratum Bung...

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Bibliographic Details
Main Authors: Jue Yang, Li Chen, Ying Yan, Jianfei Qiu, Juan Chen, Jingrui Song, Qing Rao, Yaacov Ben-David, Yanmei Li, Xiaojiang Hao
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic myeloid leukemia
BW18
Cell cycle arrest
Cell apoptosis
MAPK pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218386487

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http://www.sciencedirect.com/science/article/pii/S0753332218386487

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