Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer

The ubiquitin-proteasome system is essential for multiple physiological processes via selective degradation of target proteins and has been shown to plays a critical role in human cancer. Activation of oncogenic factors and inhibition of tumor suppressors have been shown to be essential for cancer d...

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Bibliographic Details
Main Authors: Hirohito eYamaguchi, Jennifer eHsu, Mien-Chie eHung
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Oncology
Subjects:
Akt
ERK
IKK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00015/full