A Novel Mutation in an NPXY Motif of β Integrin Reveals Phenotypes Similar to him-4/hemicentin

A Novel Mutation in an NPXY Motif of β Integrin Reveals Phenotypes Similar to him-4/hemicentin

Integrin, an αβ heterodimeric cell surface receptor for the extracellular matrix (ECM), carries two tyrosine phosphorylation motifs in the cytoplasmic tail of the β subunit. NPXY (Asn-Pro-x-Tyr) is a conserved tyrosine phosphorylation motif that binds to the phospho-tyrosine binding (PTB) domain. We...

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Bibliographic Details
Main Authors: Zhongqiang Qiu, Peter Sheesley, Jeong H. Ahn, Eun-Jeong Yu, Myeongwoo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
pat-3
basement membrane
negatively charged
glutamic acid
germ cell
male mating
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00247/full

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https://www.frontiersin.org/article/10.3389/fcell.2019.00247/full

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