Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

The spreading of pathology through neuronal pathways is likely to be the cause of the progressive cognitive loss observed in Alzheimer's disease (AD) and other neurodegenerative diseases. We have recently shown the propagation of AD pathology via cell-to-cell transfer of oligomeric amyloid beta...

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Bibliographic Details
Main Authors: Jakob Domert, Sahana Bhima Rao, Lotta Agholme, Ann-Christin Brorsson, Jan Marcusson, Martin Hallbeck, Sangeeta Nath
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid-β oligomers
Cell-to-cell transfer
Prion-like propagation
Intracellular accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000060

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http://www.sciencedirect.com/science/article/pii/S0969996114000060

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