ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans

Allele-specific distinctions in the human apolipoprotein E (APOE) locus represent the best-characterized genetic predictor of Alzheimer's disease (AD) risk. Expression of isoform APOEε2 is associated with reduced risk, while APOEε3 is neutral and APOEε4 carriers exhibit increased susceptibility...

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Bibliographic Details
Main Authors: Edward F. Griffin, Samuel E. Scopel, Cayman A. Stephen, Adam C. Holzhauer, Madeline A. Vaji, Ryan A. Tuckey, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell
Format: Article
Language:English
Published: The Company of Biologists 2019-02-01
Series:Disease Models & Mechanisms
Subjects:
ApoE
Aβ
Neurodegeneration
Alzheimer's disease
C. elegans
Online Access:http://dmm.biologists.org/content/12/2/dmm037218

Internet

http://dmm.biologists.org/content/12/2/dmm037218

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