Tetravalent dengue DNA vaccine is not immunogenic when delivered by retrograde infusion into salivary glands

Tetravalent dengue DNA vaccine is not immunogenic when delivered by retrograde infusion into salivary glands

Abstract Introduction and background A tetravalent DNA vaccine for Dengue virus is under development but has not yet achieved optimal immunogenicity. Salivary glands vaccination has been reported efficacious in rodents and dogs. We report on a pilot study testing the salivary gland as a platform for...

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Bibliographic Details
Main Authors: Guy El Helou, Todd A. Ponzio, Joseph F. Goodman, Maria Blevins, David L. Caudell, Kanakatte S. Raviprakash, Daniel Ewing, Maya Williams, Kevin R. Porter, John W. Sanders
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Tropical Diseases, Travel Medicine and Vaccines
Subjects:
Salivary gland infusion
Tetravalent dengue vaccine
DNA vaccine
Non-human primate
Online Access:http://link.springer.com/article/10.1186/s40794-020-00111-5

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http://link.springer.com/article/10.1186/s40794-020-00111-5

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