Fluorofenidone Attenuates Oxidative Stress and Renal Fibrosis in Obstructive Nephropathy via Blocking NOX2 (gp91phox) Expression and Inhibiting ERK/MAPK Signaling Pathway

Fluorofenidone Attenuates Oxidative Stress and Renal Fibrosis in Obstructive Nephropathy via Blocking NOX2 (gp91phox) Expression and Inhibiting ERK/MAPK Signaling Pathway

Background/Aims: We evaluated the therapeutic effects of fluorofenidone (AKF-PD), a novel pyridone agent, targeting oxidative stress and fibrosis in obstructive nephropathy. Methods: AKF-PD was used to treat renal interstitial fibrosis in unilateral ureteral obstruction (UUO) obstructive nephropathy...

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Bibliographic Details
Main Authors: Jiao Qin, Wen-Juan Mei, Yan-Yun Xie, Ling Huang, Qiong-Jing Yuan, Gao-Yun Hu, Li-Jian Tao, Zhang-Zhe Peng
Format: Article
Language:English
Published: Karger Publishers 2015-03-01
Series:Kidney & Blood Pressure Research
Subjects:
ERK
Losartan
Fluorofenidone
Obstructive nephropathy
NOX2 (gp91phox)
Online Access:http://www.karger.com/Article/FullText/368485

Internet

http://www.karger.com/Article/FullText/368485

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