Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection

Shigella-Induced Emergency Granulopoiesis Protects Zebrafish Larvae from Secondary Infection

Emergency granulopoiesis is a hematopoietic program of stem cell-driven neutrophil production used to counteract immune cell exhaustion following infection. Shigella flexneri is a Gram-negative enteroinvasive pathogen controlled by neutrophils. In this study, we use a Shigella-zebrafish (Danio rerio...

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Bibliographic Details
Main Authors: Alexandra R. Willis, Vincenzo Torraca, Margarida C. Gomes, Jennifer Shelley, Maria Mazon-Moya, Alain Filloux, Cristina Lo Celso, Serge Mostowy
Format: Article
Language:English
Published: American Society for Microbiology 2018-06-01
Series:mBio
Subjects:
emergency granulopoiesis
neutrophils
Shigella
stem cells
zebrafish
Online Access:https://doi.org/10.1128/mBio.00933-18

Internet

https://doi.org/10.1128/mBio.00933-18

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